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First evidence provided for the existence of the BRCA1 gene

BRCA1 gene

First evidence provided for the existence of the BRCA1 gene

BRCA1 (BReast CAncer gene 1) is a “tumor suppressor gene,” which normally produces a protein that prevents cells from growing and dividing out of control. However, certain variations of BRCA1 can disrupt its normal function, leading to increased hereditary risk for cancer. The first evidence for existence of the BRCA1 gene was provided in 1990 by the King laboratory at University of California Berkeley. After a heated international race, the gene was finally isolated in 1994. Today, researchers have identified more than 1,000 mutations of the BRCA1 gene, many of them associated with increased risk of cancer, particularly breast and ovarian cancers in women.
1990